Developmental Cell 2016

In September 2016, Matteo Perino and Gert Jan Veenstra (Radboud University, Nijmegen, The Netherlands) published a review in Developmental Cell.


Perino M, Veenstra GJ. Chromatin Control of Developmental Dynamics and Plasticity. Dev Cell. 2016 Sep 26;38(6):610-20. doi: 10.1016/j.devcel.2016.08.004.



Chromatin structure is intimately connected with gene expression and cell identity. Here we review recent advances in the field and discuss how establishment of cell identity during development is accompanied by large-scale remodeling of the epigenetic landscape and how this remodeling drives and supports lineage specification and maintenance. We discuss maternal control of the early embryonic epigenetic landscape, selective usage of enhancer clusters via 3D chromatin contacts leading to activation of transcription factor networks, and conserved regulation of developmental pathways by specific DNA demethylation of key regulatory regions. Together, these processes establish an epigenetic framework regulating different phases of embryonic development.